Kacper A. Walentynowicz, PhD

Research Associate | Cancer Biology & Genetics, MSKCC

Life Sciences Technology Innovation Fellow | Cornell SC Johnson College of Business

About Me

I'm a Research Associate with a strong background in Immuno-Oncology, currently based in New York City. My work focuses on understanding the tumor microenvironment of Glioblastoma (GBM), with a particular interest in the role of glioma-associated microglia and macrophages.

Using computational methods and animal models, I investigate the functional heterogeneity of immune cells within tumors and how they contribute to tumor progression and immune evasion. My goal is to identify new therapeutic targets and develop novel CAR-macrophage immunotherapies. I have received extensive training in novel sequencing methods, myeloid cell manipulations, computational analysis of large datasets (R, Python, and Jupyter Notebook), novel animal models of GBM, and advanced flow-cytometry analysis.

Professional Experience

Research Associate, Sloan Kettering Institute, USCurrent
2023 - Present
Developing novel CAR-macrophage immunotherapy and studying NF1 mutant gliomas. | Parada Lab
Postdoctoral Fellow, Scripps Research, US
2020 - 2023
Investigating genetic alterations in GBM and their impact on tumor microenvironment. | Janiszewska Lab

Education & Training

Life Science Entrepreneurship in Practice (Fellowship)

Cornell SC Johnson College of Business, USA

PhD, Marie Sklodowska-Curie Fellow

Nencki Institute, PL

MSc, Molecular Medicine

The Sheffield University Medical School, UK

PDP in Cancer Informatics

Imperial College London, UK

BSc (Hons), Biomedical Science

University of Wolverhampton, UK

Research Interests & Expertise

Glioblastoma (GBM) tumor microenvironment
Single-cell heterogeneity of cancer and immune cells
Glioma-associated microglia and macrophages (GAMs)
Molecular mechanisms of immune evasion in brain tumors
Translational research for novel GBM therapies

Core Research Focus

Selected Publications

Figure 1 from the Cell Reports paper

25

Single-cell heterogeneity of EGFR and CDK4 co-amplification is linked to immune infiltration in glioblastoma

Kacper A Walentynowicz, Dalit Engelhardt, et al.

Cell Reports, 2023 Mar 28;42(3):112235.

Figure from the Nature Communications paper

405

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages

Natalia Ochocka, Pawel Segit, Kacper A Walentynowicz, et. al.

Nature Communications, 2021 Feb 19;12(1):1111.

Figure from the Frontiers in Immunology paper

61

In Search for Reliable Markers of Glioma-Induced Polarization of Microglia

Kacper A Walentynowicz, Natalia Ochocka, et al.

Frontiers in Immunology, 2018 Jun 15;9:1329.

Graphical abstract from the Laboratory Investigation paper

568

Immune microenvironment of gliomas

Anna Gieryng, Dominika Pszczolkowska, Kacper A Walentynowicz, et al.

Laboratory Investigation, 2017 May;97(5):498-518.

Google Scholar Statistics

1,074 Total Citations

5 h-index

5 i10-index

Statistics last updated: Dec 28th, 2025

Contact & Profiles